How IL-6 expression is regulated in human neutrophils has remained unclear. Here the authors show, using highly purified neutrophils, that TLR8 or TLR4 signalling activates latent enhancers and cooperates with autocrine TNFα to induce IL-6transcription.
Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils