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Click-electrochemistry for the rapid labeling of virus, bacteria and cell surfaces
Methods for direct covalent ligation of microorganism surfaces are scarce. Here, the authors developed a rapid electrochemical process for the direct covalent ligation and labelling of the surfaces of virus, bacteria and cells using N-methylluminol, a fully tyrosine-selective protein anchoring group.
- Sébastien Depienne
- , Mohammed Bouzelha
- & Sébastien G. Gouin
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Article
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Controllable DNA hybridization by host–guest complexation-mediated ligand invasion
Direct dissociation of nucleic acid duplex structures without heating or specific binding proteins is challenging. Here the authors use the cucurbit[7]uril-based host–guest system to construct a ligand-invasion pathway for controllable DNA hybridisation.
- Lin Xiao
- , Liang-Liang Wang
- & Liang Xu
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Article
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Chemical zymogens for the protein cysteinome
Reversible on/off switches for enzyme activity are foundational in nature but are challenging to design using tools of synthetic chemistry. Here the authors design chemical zymogens amenable for activation via biomolecular interactions.
- Mireia Casanovas Montasell
- , Pere Monge
- & Alexander N. Zelikin
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Article
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Chirality transmission in macromolecular domains
Chiral communication can propagate in secondary structures within the effective intermolecular force (IMF) range but it is not known whether long-range chiral communication exists between tertiary peptide structures. Here, the authors use single-molecule force spectroscopy to investigate chiral interaction between DNA duplexes/triplexes and peptide coiled-coils and demonstrate chiral communication beyond the IMF distance.
- Shankar Pandey
- , Shankar Mandal
- & Hanbin Mao
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Article
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Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach
Amphiphilic protein-polymer conjugates remain largely unexplored due to synthetic protocols being complex. Here the authors explore an oxygen tolerant, photoinduced reversible-deactivated radical polymerization approach, which readily affords quantitative yields within 2 h and thus avoids damage to the secondary structure of the proteins.
- Alexis Theodorou
- , Evelina Liarou
- & Kelly Velonia
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Article
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Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
Mitochondria are a source of reactive oxygen species, which can be exploited to induce the death of cancer cells. Here, the authors use nanoparticles that release camptothecin in a reactive oxygen species dependent manner, leading to cancer cell death.
- Wenjia Zhang
- , Xianglong Hu
- & Da Xing
Site-selected in situ polymerization for living cell surface engineering