Biomaterials – vaccines articles within Nature Communications

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  • Article
    | Open Access

    While glycolysis inhibition impairs cancer cell tumourigenic capacities, it also affects immune cells anti-tumour activity. Here, the authors show that rescuing glycolytic inhibition of dendritic cells improves the efficacy of combining immunotherapy with glycolysis inhibition.

    • Sahil Inamdar
    • , Abhirami P. Suresh
    •  & Abhinav P. Acharya

  • Article
    | Open Access

    Electrospray deposition is a promising technique for depositing functional coatings at the micro-/nano-scale. Here, the authors establish the necessary conditions for high efficiency electrospray deposition of small targets, establishing promise as an alternative to other conformal coating methods.

    • Sarah H. Park
    • , Lin Lei
    •  & Jonathan P. Singer

  • Article
    | Open Access

    Delivery of immune therapy drugs to tumours might be hampered by their limited bioavailability and the difficulty of targeting complex exogenous compounds. Here authors trigger immunologic cell death, via activating tumour-cell-intrinsic pathways via CRISPR-based nanotechnology to enable efficient anti-tumour immune response in mouse models of melanoma.

    • Ning Wang
    • , Chao Liu
    •  & Changyang Gong

  • Article
    | Open Access

    Multiple sclerosis is a debilitating autoimmune disease, for which therapy is not curative, only slowing down progression at the expense of general immune suppression. Here authors show that in a mouse model of multiple sclerosis, disease progression could be halted or even reversed by a nanovaccine, composed of reactive oxygen species scavenging cerium oxide nanoparticles, which establishes immune tolerance against the relevant autoantigen.

    • Thanh Loc Nguyen
    • , Youngjin Choi
    •  & Jaeyun Kim

  • Article
    | Open Access

    Autologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulatory micrometer-sized vesicles, promoting anti-tumor immune responses in preclinical models.

    • Yuxin Guo
    • , Shao-Zhe Wang
    •  & Fu-Gen Wu

  • Article
    | Open Access

    Stimuli-responsive nanomaterials offer the opportunity to exploit nanoscale cooperativity to improve the precision of diagnostic or therapeutic outcomes. Here, the authors report the design, synthesis and characterization of a series of degradable ultra-pH sensitive polymers that amplify small acidic pH changes to efficacious therapeutic outputs.

    • Xu Wang
    • , Jonathan Wilhelm
    •  & Jinming Gao

  • Article
    | Open Access

    The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast cancer models.

    • Hua Wang
    • , Alexander J. Najibi
    •  & David J. Mooney

  • Article |

    Immune responses are induced in the organized, cytokine-rich environment of lymph nodes, which can be mimicked by biomaterials. Here the authors show that injectable sponge-like gels decorated with immunostimulatory factors attract dendritic cells and boost antitumour immune responses in mice.

    • Sidi A. Bencherif
    • , R. Warren Sands
    •  & David J. Mooney

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