Central control of bone remodelling articles within Nature Communications

Featured

• Article
  21 February 2023 | Open Access

  Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

  Despite the importance of osteoclast secretory lysosomes in bone digestion, the proteins that regulate them remain ill defined. Here, the authors identify Slc37a2 as a secretory lysosome sugar transporter that is required for maintenance of skeletal bone mass.

  • Pei Ying Ng
  • , Amy B. P. Ribet
  •  & Nathan J. Pavlos

• Article
  23 June 2020 | Open Access

  Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

  Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.

  • Eran Assaraf
  • , Ronen Blecher
  •  & Elazar Zelzer

• Article
  20 February 2017 | Open Access

  SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

  The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast RANKL production and excess osteoclastogenesis.

  • Zhan Xu
  • , Matthew B. Greenblatt
  •  & Weiguo Zou