Targeted bone remodelling articles within Nature Communications

Featured

  • Article
    | Open Access

    Fractured long bones regenerate through osteo-angiogenic coupling, but how calvarial bone healing occurs is not yet clear. Here they show that regenerating blood vessels separate from co-migrating progenitors in calvarial bones, resulting in osteoblasts mineralizing a previously vascularized lesion.

    • M. Gabriele Bixel
    • , Kishor K. Sivaraj
    •  & Ralf H. Adams

  • Article
    | Open Access

    Angelozzi et al. uncover key mechanisms involved in physiological and pathological bone mass remodeling by showing that SOXC transcription factors regulate the bone formation and resorption balance via critical roles in LepR+ mesenchymal stem cells.

    • Marco Angelozzi
    • , Anirudha Karvande
    •  & Véronique Lefebvre

  • Article
    | Open Access

    The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated osteolytic bone disease

    • Janik Engelmann
    • , Jennifer Zarrer
    •  & Sonja Loges

  • Article
    | Open Access

    The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.

    • Jialiang S. Wang
    • , Tushar Kamath
    •  & Marc N. Wein

  • Article
    | Open Access

    LncRNAs are implicated in the pathogenesis of a number of diseases. Here, the authors show that the lncRNA Nron suppresses bone resorption, and show that delivery of a functional motif of Nron increases bone mass in mouse models of osteoporosis.

    • Fujun Jin
    • , Junhui Li
    •  & Xiaogang Wang

  • Article
    | Open Access

    BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated bone formation in mice.

    • Chao Liang
    • , Songlin Peng
    •  & Ge Zhang

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