Cancer genomics articles within Nature Communications

Featured

  • Article
    | Open Access

    Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.

    • Cecil Han
    • , Lifeng Yang
    •  & Xiongbin Lu

  • Article
    | Open Access

    Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations.

    • Pascal Gellert
    • , Corrinne V. Segal
    •  & Peter Donnelly

  • Article
    | Open Access

    Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.

    • Zhaohui Gu
    • , Michelle Churchman
    •  & Charles G. Mullighan

  • Article
    | Open Access

    Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.

    • Yu Liu
    • , Jianjun Zhang
    •  & Yanning Gao

  • Article
    | Open Access

    Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitroand improves survival in mice.

    • Jin-Ah Kim
    • , Ying Tan
    •  & Xiao-Song Wang

  • Article
    | Open Access

    Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.

    • Sam Behjati
    • , Gunes Gundem
    •  & Peter J. Campbell

  • Article
    | Open Access

    Pre-clinical studies have shown that TP53 mutations can account for acquired resistance to HDM2 antagonists. This study provides clinical evidence for the emergence of TP53mutations in circulating cell-free DNA, seen in 5 out of 20 de-differentiated liposarcoma patients treated with an HDM2 antagonist.

    • Joonil Jung
    • , Joon Sang Lee
    •  & James Watters

  • Article
    | Open Access

    Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.

    • Vida Chitsazzadeh
    • , Cristian Coarfa
    •  & Kenneth Y. Tsai

  • Article
    | Open Access

    A recently emerged infectious cancer has caused the near extinction of the Tasmanian devil, but some populations persist. Here, Epstein et al. provide evidence for possible resistance via rapid evolution in two genomic regions that contain cancer-related immune response genes.

    • Brendan Epstein
    • , Menna Jones
    •  & Andrew Storfer

  • Article
    | Open Access

    Response to drug therapy in colorectal cancer (CRC) patients has been associated with tumour heterogeneity. Here the authors analyse DNA copy number aberrations in primary tumours from CRC patients and identify genetic variants that influence drug response.

    • Josien C. Haan
    • , Mariette Labots
    •  & Gerrit A. Meijer

  • Article |

    Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.

    • Ghislaine Scelo
    • , Yasser Riazalhosseini
    •  & G. Mark Lathrop

  • Article
    | Open Access

    Loss-of-function mutations in tumour suppressor genes are associated with oesophageal adenocarcinoma (EAC), but the mechanisms underlying EAC development remain unclear. Here, the authors show that EACs present a high frequency of genomic catastrophes resulting in amplification of potent oncogenes.

    • Katia Nones
    • , Nicola Waddell
    •  & Andrew P. Barbour

  • Article |

    Analyses of genome and transcriptome data are unable to accurately predict protein levels and function in tumour samples. Here, the authors carry out a comprehensive protein analysis in 3,467 samples from the cancer genome atlas, providing a resource to study the prognostic and therapeutic potential of tumour proteins.

    • Rehan Akbani
    • , Patrick Kwok Shing Ng
    •  & Gordon B. Mills

  • Article
    | Open Access

    The genetic basis of gastric cancer, the fourth most common cancer worldwide, remains poorly understood. Here, the authors sequence and analyse the exomes and transcriptomes of primary gastric tumours and cell lines, and identify a ZAK kinase isoform that may have an oncogenic role in gastric cancer.

    • Jinfeng Liu
    • , Mark McCleland
    •  & Zemin Zhang

  • Article
    | Open Access

    Multiple myeloma is a malignant plasma cell disorder with a complex molecular pathogenesis. Here, the authors perform whole-exome sequencing, copy-number profiling and cytogenetic analysis in 84 myeloma samples and highlight the diversity and evolution of the mutational profile underlying the disease.

    • Niccolo Bolli
    • , Hervé Avet-Loiseau
    •  & Nikhil C. Munshi

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