Central nervous system infections articles within Nature Communications

Featured

• Article
  23 May 2024 | Open Access

  HIV-1 RNA in extracellular vesicles is associated with neurocognitive outcomes

  Despite effective antiviral drugs, HIV-1 transcripts can be found in extracellular vesicles (EVs) in people living with HIV-1. Comparing EVs from serum and cerebrospinal fluid (CSF), the authors show compartmentalized defective viral transcripts that are enriched in the CSF and corelate with cognitive dysfunction.

  • Catherine DeMarino
  • , Julia Denniss
  •  & Avindra Nath

• Article
  21 March 2024 | Open Access

  Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease

  In comparison to PeV-A1, infection with PeV-A3 is associated with neurological illness in infants. Here, using brain organoids, the authors suggest that the innate inflammatory response as the underlying reason, and not replication kinetics.

  • Pamela E. Capendale
  • , Inés García-Rodríguez
  •  & Katja C. Wolthers

• Article
  29 December 2022 | Open Access

  Dynamic ¹⁸F-Pretomanid PET imaging in animal models of TB meningitis and human studies

  Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies.

  • Filipa Mota
  • , Camilo A. Ruiz-Bedoya
  •  & Sanjay K. Jain

• Article
  09 November 2022 | Open Access

  Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

  Both acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection.

  • Manina M. Etter
  • , Tomás A. Martins
  •  & Gregor Hutter