Computational platforms and environments articles within Nature Communications

Featured

• Article
  15 May 2018 | Open Access

  Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

  Recombination contributes to HIV evolution in patients, but its identification can be difficult. Here, the authors develop a computational tool called RAPR to track recombination in patients, identify recombination hot spots, and show contribution of recombination to antibody escape.

  • Hongshuo Song
  • , Elena E. Giorgi
  •  & Feng Gao

• Article
  16 November 2017 | Open Access

  Shaping bacterial population behavior through computer-interfaced control of individual cells

  Individual bacteria interact with each other and their environment to produce population-level patterns of gene expression. Here the authors use an automated platform combined with optogenetic feedback to manipulate population behaviors through dynamic control of individual cells.

  • Remy Chait
  • , Jakob Ruess
  •  & Călin C. Guet

• Article
  11 December 2015 | Open Access

  A new tool called DISSECT for analysing large genomic data sets using a Big Data approach

  Availability of computing power can limit computational analysis of large genetic and genomic datasets. Here, Canela-Xandri, et al. describe a software called DISSECT that is capable of analyzing large-scale genetic data by distributing the work across thousands of networked computers.

  • Oriol Canela-Xandri
  • , Andy Law
  •  & Albert Tenesa

• Article | 19 January 2015

  Biological interpretation of genome-wide association studies using predicted gene functions

  Identifying which genes and pathways explain genetic associations is challenging. Here, the authors present DEPICT, a tool for gene prioritization, pathway analysis and tissue/cell-type enrichment analysis that can be used to generate testable hypotheses from genetic association studies.

  • Tune H. Pers
  • , Juha M. Karjalainen
  •  & Lude Franke