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Article
| Open Access
Afferent convergence to a shared population of interneuron AMPA receptors
Glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission called spillover. Here, the authors find in the cerebellar cortex that glutamate spillover from climbing fibers activates synaptic AMPA receptors of molecular layer interneurons, allowing glutamate from an unconnected pathway to co-opt postsynaptic receptors.
- Reagan L. Pennock
- , Luke T. Coddington
- & Jacques I. Wadiche
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Article
| Open Access
An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning
How glial cells like astrocytes shape complex brain functions remains unclear. Here, the authors identified an astrocyte-mediated excitatory signaling loop between neurons and their own dendritic signal integration that supports spatial memory.
- Kirsten Bohmbach
- , Nicola Masala
- & Christian Henneberger
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Article
| Open Access
Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo
The influence of sharp-wave ripples (SPW-Rs) on dendritic computation remains poorly understood. Here, the authors demonstrate the existence of SPW-R associated, branch-specific, dendritic spikes which serve as a temporal and spatial coincidence detectors during SPW-R-doublets in PV+ interneuron dendrites of awake mice.
- Linda Judák
- , Balázs Chiovini
- & Balázs Rózsa
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Article
| Open Access
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.
- Farhan Ali
- , Danielle M. Gerhard
- & Alex C. Kwan
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Article
| Open Access
Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells
Complex spike burst discharges of hippocampal neurons are proposed to be important for plasticity. Here, the authors report that in CA3 pyramidal neurons complex bursts generated by intrinsic mechanisms, can represent heterogeneous input-output functions and are regulated by HCN and Kv2 channels.
- Snezana Raus Balind
- , Ádám Magó
- & Judit K. Makara
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Article
| Open Access
Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling
‘Analogue’ modulation by somatic membrane potentials can modify ‘digital’ axonal action potentials. Here, the authors show that analogue modulation can occur in back-propagating dendritic action potentials and calcium signals, leading to signal enhancement or attenuation in a location-dependent manner.
- János Brunner
- & János Szabadics
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Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons
During development, neurons prune their axons and dendrites to eliminate excessive or inappropriate connections initially formed but the mechanistic details of the pruning process are not completely understood. Here the authors visualize pruning events in dendritic branches in Drosophilaand study the role of calcium transients and endocytosis in this process.
- Takahiro Kanamori
- , Jiro Yoshino
- & Kazuo Emoto
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Article
| Open Access
Dendritic geometry shapes neuronal cAMP signalling to the nucleus
Neurons have complex dendritic trees but the rules governing the propagation of signals from dendrites to nuclei remain unclear. Here the authors combine diffusion-reaction modelling and live imaging to investigate the mechanisms regulating cAMP signalling in neurons and find that dendritic tree geometry shapes synapse-to-nucleus signalling.
- Lu Li
- , Nicolas Gervasi
- & Jean-Antoine Girault
Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells