Drug screening articles within Nature Communications

Featured

• Article | 03 September 2013

  Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

  Scn1a encodes a voltage-gated sodium channel and mutations in this gene are implicated in epilepsy. Baraban et al. find that the compound clemizole is effective in blocking epilepsy-like seizures zebrafish with an Scn1adevelopmental mutation.

  • Scott C. Baraban
  • , Matthew T. Dinday
  •  & Gabriela A. Hortopan

• Article | 12 February 2013

  High-throughput hyperdimensional vertebrate phenotyping

  Large-scale screening of animal phenotypes requires automated detection and analysis of complex morphological information. Here, Yanik and colleagues present an imaging system based on optical projection tomography that generates micrometre-resolution 3D images of zebrafish larvae with within tens of seconds per animal.

  • Carlos Pardo-Martin
  • , Amin Allalou
  •  & Mehmet Fatih Yanik

• Article | 22 November 2011

  Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library

  Metabolism is altered in many diseases, and monitoring metabolic changes during treatment could facilitate investigations into treatment efficacy and cellular responses. This study reports an NMR-based method to screen the metabolic responses of mammalian cells to drugs.

  • Stefano Tiziani
  • , Yunyi Kang
  •  & Giovanni Paternostro