Intestinal stem cells articles within Nature Communications

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  • Article
    | Open Access

    Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.

    • David M. Gay
    • , Rachel A. Ridgway
    •  & Owen J. Sansom

  • Article
    | Open Access

    Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

    • Nicola Fenderico
    • , Revina C. van Scherpenzeel
    •  & Madelon M. Maurice

  • Article
    | Open Access

    The mechanisms regulating intestinal stem cell elimination remain unclear. Here, the authors identify that the pro-apoptotic protein ARTS (a Septin4 isoform) interacts with XIAP in the intestinal stem cell niche to  regulate stem cell survival during intestinal homeostasis and regeneration.

    • Elle Koren
    • , Yahav Yosefzon
    •  & Yaron Fuchs

  • Article
    | Open Access

    Colony stimulating factor 1 controls the growth and differentiation of macrophages. Here the authors demonstrate that its blockade depletes gut macrophages and indirectly affects gut epithelial cell differentiation as the macrophages help maintain the Paneth and stem cells in intestinal crypts.

    • Anuj Sehgal
    • , David S. Donaldson
    •  & Neil A. Mabbott

  • Article
    | Open Access

    Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated adenoma formation due to lack of cell competition.

    • D. J. Huels
    • , L. Bruens
    •  & O. J. Sansom

  • Article
    | Open Access

    Stress response JNK signalling is important for cell death-induced regeneration. Here the authors show in adultDrosophilaenterocytes that ATF3 regulates the expression of Raw, a JNK antagonist, to control intestinal regeneration and barrier function in response to infection.

    • Jun Zhou
    • , Bruce A. Edgar
    •  & Michael Boutros

  • Article
    | Open Access

    There are two technical impediments for using purified Wnt proteins in serum-free stem cell cultures: rapid loss of activity and toxicity of detergents to stem cell self-renewal. Here, the authors show that lipid-stabilized Wnt3a can establish long-term culture of human intestinal and liver organoids.

    • Nesrin Tüysüz
    • , Louis van Bloois
    •  & Derk ten Berge

  • Article
    | Open Access

    Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediated repression of stem cell signature genes.

    • Zhen Qi
    • , Yehua Li
    •  & Ye-Guang Chen

  • Article
    | Open Access

    It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a compensatory release of WNT-related factors.

    • Emanuel Berger
    • , Eva Rath
    •  & Dirk Haller

  • Article
    | Open Access

    The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.

    • Subhrajit Saha
    • , Evelyn Aranda
    •  & Jeffrey W. Pollard

  • Article
    | Open Access

    It is unclear why certain tissues are more susceptible to the consequences of aneuploidy. Here, in Drosophila, Gogendeau et al.identify aneuploidy as the cause of lengthened G1 and premature differentiation in both neural and adult intestinal stem cells, which prevents cells with abnormal genomes from cycling.

    • Delphine Gogendeau
    • , Katarzyna Siudeja
    •  & Renata Basto

  • Article |

    The Hippo pathway plays a role in regulating organ size and stem cell renewal but the regulatory mechanisms that fine-tune this pathway are not well understood. Here the authors report on the role of NEDD4 as a negative regulator of the Hippo signalling components, WW45 and LATS kinase, and in controlling cell proliferation and intestinal stem cell homeostasis.

    • Sung Jun Bae
    • , Myungjin Kim
    •  & Jae Hong Seol

  • Article
    | Open Access

    It has been proposed that stem cells use nonrandom chromosome segregation to avoid the accumulation of replication-induced mutations. Here, the authors examine intestinal epithelial stem cell division and show, using label exclusion and retention assays, that the cells segregate their chromosomes randomly.

    • Marion Escobar
    • , Pierre Nicolas
    •  & Catherine Legraverend

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