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Article
| Open Access
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes
Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.
- Rupert L. Mayer
- , Rein Verbeke
- & Francis Impens
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Article
| Open Access
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells.
- Fabien Thery
- , Lia Martina
- & Francis Impens
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IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes
Autophagy is critical for pathogen clearance by innate immune cells. Here the authors show that IRF8 is activated in response to autophagy-inducing stimuli, promotes autophagic progression by driving transcription of autophagy genes and is critical for clearance of intracellular bacteria.
- Monica Gupta
- , Dong-Mi Shin
- & Keiko Ozato
The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells