Lymphatic vessels articles within Nature Communications

Featured

• Article
  30 November 2022 | Open Access

  Deciphering the heterogeneity of the Lyve1⁺ perivascular macrophages in the mouse brain

  Perivascular macrophages (pvMs) are important for brain drainage and immune regulation. Here the authors analyse various reporter mouse strains for finer mapping of pvM subsets and lineage differentiation, and propose CX3CR1negative and CD45low as additional markers of intermediate pvMs for studying this heterogenous population.

  • C. Siret
  • , M. van Lessen
  •  & S. A. van de Pavert

• Article
  27 January 2020 | Open Access

  Lymphatic endothelial cells prime naïve CD8⁺ T cells into memory cells under steady-state conditions

  Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8⁺ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8⁺ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

  • Efthymia Vokali
  • , Shann S. Yu
  •  & Melody A. Swartz

• Article
  01 August 2018 | Open Access

  Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

  Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and dendritic cell migration and ameliorate contact hypersensitivity in mouse models.

  • Wenji Piao
  • , Yanbao Xiong
  •  & Jonathan S. Bromberg

• Article
  11 December 2017 | Open Access

  Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

  Viral infection and vaccination both induce lasting persistence of antigens for protective responses. Here the authors show that migratory dendritic cells, independent of the transcription factor BatF3 for their development, contribute to “archived antigen” exchange with lymphatic endothelial cells.

  • Ross M. Kedl
  • , Robin S. Lindsay
  •  & Beth A. Jirón Tamburini

• Article
  10 February 2017 | Open Access

  Topical tacrolimus for the treatment of secondary lymphedema

  Secondary lymphedema is a debilitating disease with no cure. Here the authors show that topical application of an FDA-approved anti-T cell drug tacrolimus potently prevents development and alleviates pathologic changes of established lymphedema in mice, suggesting a new treatment for human patients.

  • Jason C. Gardenier
  • , Raghu P. Kataru
  •  & Babak J. Mehrara

• Article
  01 March 2016 | Open Access

  Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

  Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis.

  • Caroline P. Le
  • , Cameron J. Nowell
  •  & Erica K. Sloan

• Article | 04 February 2015

  T_H2 cells and their cytokines regulate formation and function of lymphatic vessels

  Lymphatic vessels remodel in response to inflammatory conditions and T-cell-secreted cytokines. Here, the authors show that T helper type 2 cells inhibit lymphangiogenesis by secreting IL-4 and IL-13, and that blockade of these cytokines can alleviate allergic asthma symptoms by improving the lymphatic function in mice.

  • Kihyuk Shin
  • , Raghu P. Kataru
  •  & Seung-Hyo Lee