Featured
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Article
| Open AccessMiR-21-5p modulates LPS-induced acute injury in alveolar epithelial cells by targeting SLC16A10
- Huanan Zeng
- , Yuqing Zhou
- & Wei Liu
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Article
| Open AccessSynthesis and anti-inflammatory activities of two new N-acetyl glucosamine derivatives
- Zhichang Zhang
- , Weicheng Wang
- & Ameer E. Hassan
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Article
| Open AccessDetection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
- Krzysztof Pastuszak
- , Michał Sieczczyński
- & Anna J. Żaczek
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Article
| Open AccessA quantitative comparison of urine centrifugation and filtration for the isolation and analysis of urinary nucleic acid biomarkers
- Liz-Audrey Kounatse Djomnang
- , Carol Li
- & Iwijn De Vlaminck
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Article
| Open AccessA bicentric retrospective study of the correlation of EAU BCR risk groups with 18F-PSMA-1007 PET/CT detection in prostate cancer biochemical recurrence
- Nathan Poterszman
- , Charles Merlin
- & François Somme
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Article
| Open AccessExploring the mystery of colon cancer from the perspective of molecular subtypes and treatment
- Wenhong Lu
- , Qiwei Wang
- & Wenpeng Luo
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Article
| Open AccessCRISPR/Cas9 genome editing of CCR5 combined with C46 HIV-1 fusion inhibitor for cellular resistant to R5 and X4 tropic HIV-1
- Wannisa Khamaikawin
- , Chonticha Saisawang
- & Suradej Hongeng
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Article
| Open AccessAdvancing molecular modeling and reverse vaccinology in broad-spectrum yellow fever virus vaccine development
- Ohana Leticia Tavares da Silva
- , Maria Karolaynne da Silva
- & Jonas Ivan Nobre Oliveira
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Article
| Open AccessChronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway
- Yiyang Che
- , Yuuki Shimizu
- & Toyoaki Murohara
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Article
| Open AccessKlotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake
- Hyun Jun Jung
- , Truyen D. Pham
- & Lama Al-Qusairi
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Article
| Open AccessPeripheral blood transcriptomic profiling of molecular mechanisms commonly regulated by binge drinking and placebo effects
- Amol Carl Shetty
- , John Sivinski
- & Chamindi Seneviratne
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Article
| Open AccessOptimization of ultrasonic pretreatment and analysis of chlorogenic acid in potato leaves
- Xin Wang
- , Xianyun Gong
- & Binbin Lin
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Article
| Open AccessA combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
- Rui Zheng
- & Lars Lind
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Article
| Open AccessLRBA, a BEACH protein mutated in human immune deficiency, is widely expressed in epithelia, exocrine and endocrine glands, and neurons
- Eleni Roussa
- , Pavel Juda
- & Manfred W. Kilimann
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Article
| Open AccessPeriodic heat waves-induced neuronal etiology in the elderly is mediated by gut-liver-brain axis: a transcriptome profiling approach
- Subhajit Roy
- , Punnag Saha
- & Saurabh Chatterjee
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Article
| Open AccessDifferential expression of angiogenesis-related genes ‘VEGF’ and ‘angiopoietin-1’ in metastatic and EMAST-positive colorectal cancer patients
- Amir Torshizi Esfahani
- , Somayeh Mohammadpour
- & Ehsan Nazemalhosseini-Mojarad
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Article
| Open AccessDesigning of a new transdermal antibiotic delivery polymeric membrane modified by functionalized SBA-15 mesoporous filler
- Mahya Samari
- , Soheila Kashanian
- & Hossein Derakhshankhah
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Article
| Open AccessHMGN1 loss sensitizes lung cancer cells to chemotherapy
- Xianli Wu
- , Geqi Cai
- & Wenchu Lin
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Editorial
| Open AccessMitochondrial dynamics: updates and perspectives
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
- Kezhong Zhang
- & Ježek Petr
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Article
| Open AccessDroplet based whole genome amplification for sequencing minute amounts of purified Mycobacterium tuberculosis DNA
- Anzaan Dippenaar
- , Nabila Ismail
- & Robin M. Warren
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Article
| Open AccessBody mass index is an overlooked confounding factor in existing clustering studies of 3D facial scans of children with autism spectrum disorder
- Martin Schwarz
- , Jan Geryk
- & Veronika Moslerová
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Article
| Open AccessMiR-204-5p may regulate oxidative stress in myopia
- Bo Jiang
- , Nan Hong
- & Feng Dong
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Article
| Open AccessTreadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats
- Xianbin Wang
- , Yingxue Fu
- & Shuang Wu
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Article
| Open AccessS100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps
- Nasibeh Khayer
- , Maryam Jalessi
- & Zahra Azad
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Article
| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq
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Article
| Open AccessXPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways
- Nitin Chakravarti
- , Amy Boles
- & Pierluigi Porcu
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Article
| Open AccessAn increase in ER stress and unfolded protein response in iPSCs-derived neuronal cells from neuronopathic Gaucher disease patients
- Tanapat Pornsukjantra
- , Nongluk Saikachain
- & Nithi Asavapanumas
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Article
| Open AccessMolecular epidemiology and hematological profiles of hemoglobin variants in southern Thailand
- Wanicha Tepakhan
- , Sataron Kanjanaopas
- & Saristha Buathong
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Article
| Open AccessSMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
- Hannah Åbacka
- , Samuele Masoni
- & Karin Lindkvist-Petersson
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Article
| Open AccessC16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer
- Yu Hashimoto
- , Yoshio Tokumoto
- & Yoichi Hiasa
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Article
| Open AccessAnalysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
- Nilanjana Ghosh
- , Carl Lejonberg
- & J. Gustav Smith
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Article
| Open AccessMolecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer
- Tahani Bakhsh
- , Safiah Alhazmi
- & Ahmed Bahieldin
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Article
| Open AccessTranscriptomics analysis of long non-coding RNAs in smooth muscle cells from patients with peripheral artery disease and diabetes mellitus
- Yankey Yundung
- , Shafeeq Mohammed
- & Jaroslav Pelisek
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Article
| Open AccessMetabotropic glutamate receptor genetic variants and peripheral receptor expression affects trait scores of autistic probands
- Nilanjana Dutta
- , Mahasweta Chatterjee
- & Kanchan Mukhopadhyay
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Article
| Open AccessThe polymorphism analysis for CD36 among platelet donors
- Qilu Lyu
- , Yuwei Lin
- & Jue Wang
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Article
| Open AccessPossible involvement of zinc transporter ZIP13 in myogenic differentiation
- Masaki Shoji
- , Takuto Ohashi
- & Takashi Kuzuhara
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Article
| Open AccessIntranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models
- Takuma Ide
- , Kumi Izawa
- & Jiro Kitaura
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Article
| Open AccessM1 macrophages polarized by crude polysaccharides isolated from Auricularia polytricha exhibit anti-tumor effect on human breast cancer cells
- Sunita Nilkhet
- , Kuljira Mongkolpobsin
- & Siriporn Chuchawankul
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Article
| Open AccessRSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells
- Assim Hayderi
- , Ashok K. Kumawat
- & Liza U. Ljungberg
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Article
| Open AccessIntra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats
- Pengcui Li
- , Yangyang Gao
- & Xiaochun Wei
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Article
| Open AccessTargeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method
- Veronika Mikhaylova
- , Madison Rzepka
- & Zhoutao Chen
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Article
| Open AccessNeuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death
- Wudtipong Vongthip
- , Sunita Nilkhet
- & Seung Joon Baek
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Article
| Open AccessClinically significant changes in genes and variants associated with epilepsy over time: implications for re-analysis
- Alan J. Robertson
- , Khoa A. Tran
- & Nicola Waddell
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Article
| Open AccessTenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells
- Sha Lv
- , Qianrong Pan
- & Xueping Lei
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Article
| Open AccessNeutrophil to lymphocytes ratio in deep infiltrating endometriosis as a new toll for clinical management
- Mattia Dominoni
- , Marianna Francesca Pasquali
- & Barbara Gardella
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Article
| Open AccessThe cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts
- Jiunn-Min Shieh
- , Yih-Jeng Tsai
- & Wen-Bin Wu
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Article
| Open Access5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis
- Jiraroch Meevassana
- , Shananya Varophas
- & Nakarin Kitkumthorn
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Article
| Open AccessA new DNA aptamer which binds to SARS-CoV-2 spike protein and reduces pro-inflammatory response
- Woong Kim
- , Eun Su Song
- & Seok-Jun Kim
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Article
| Open AccessCardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults
- Jiawen Liao
- , Jesse A. Goodrich
- & Zhanghua Chen