Monokines articles within Nature Communications

Featured

• Article
  20 July 2023 | Open Access

  IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

  The turnover of interleukin-1β, a cytokine that plays important roles in both physiologic and pathologic inflammatory processes, is regulated by proteolytic maturation of the pro-form and by ubiquitin-mediated degradation. Here authors identify the specific ubiquitin E3 ligases that form an active complex with UBE2L3, a ubiquitin conjugating enzyme, that target pro-IL-1β for proteasomal breakdown.

  • Vishwas Mishra
  • , Anna Crespo-Puig
  •  & Avinash R. Shenoy

• Article
  15 November 2017 | Open Access

  Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

  Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanced GPR65 expression.

  • M. H. Al-Mossawi
  • , L. Chen
  •  & P. Bowness