Nephritis articles within Nature Communications

Featured

• Article
  15 November 2023 | Open Access

  Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease

  Mucosal associated invariant T (MAIT) cells reside in barrier organs, but their contribution to inflammatory processes in the kidneys is not fully known. Here authors find by single cell RNA sequencing that among the different MAIT cell subtypes found at steady state, a population with MAIT17 signature is expanded in both human crescentic glomerulonephritis and its mouse model, and these cells may play protective role in the disease.

  • Ann-Christin Gnirck
  • , Marie-Sophie Philipp
  •  & Jan-Eric Turner

• Article
  02 June 2020 | Open Access

  Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5

  Alport syndrome is a progressive inherited nephritis accompanied by sensorineural loss of hearing and ocular abnormalities, for which there is currently no effective therapy. Here, the authors develop an exon-skipping therapy using an antisense-oligonucleotide and show it is effective in mouse models.

  • Tomohiko Yamamura
  • , Tomoko Horinouchi
  •  & Kandai Nozu

• Article
  12 October 2017 | Open Access

  Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

  Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.

  • Ling Guo
  • , Shi Luo
  •  & Zhirong Zhang