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Article
| Open Access
Coordination of alternative splicing and alternative polyadenylation revealed by targeted long read sequencing
In this study using a targeted long read RNA sequencing approach called PL-Seq, the authors uncover coordination of alternative splicing and alternative polyadenylation within individual genes in Drosophila melanogaster.
- Zhiping Zhang
- , Bongmin Bae
- & Pedro Miura
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Article
| Open Access
A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development
The molecular mechanisms ensuring early face, brain, and skin formation are unclear. Here, the authors uncover a posttranslational pathway that controls cytoskeletal signaling circuits to coordinate ectodermal patterning and neurulation.
- Anthony J. Asmar
- , Shaun R. Abrams
- & Achim Werner
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Article
| Open Access
Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling
Apical constriction is known to be critical for neural tube closure, but the signals that induce this process have not been fully characterized. Here Yoon et al. identify a signaling complex that instructs actomyosin contractions during apical constriction and show that it is required for neural tube closure.
- Jaeho Yoon
- , Jian Sun
- & Ira O. Daar
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Article
| Open Access
Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2
Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity, and ultimately link PCP defects with idiopathic scoliosis.
- Maria Jussila
- , Curtis W. Boswell
- & Brian Ciruna
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Article
| Open Access
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial and ER stress, leading to neural tube defects.
- Penghua Yang
- , Cheng Xu
- & Peixin Yang
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Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure
Epithelial folding is a critical process for vertebrate neural tube closure, however, its spatial regulation is largely unknown. Here Ossipova et al. show that Rab11-positive recycling endosomes acquire bilaterally symmetric distribution in the Xenopusneural plate, and that this polarization is essential for neural tube formation.
- Olga Ossipova
- , Kyeongmi Kim
- & Sergei Y. Sokol
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Hemichordate neurulation and the origin of the neural tube
The evolutionary origins of the chordate neural tube and notochord are unclear. Here the authors show the expression patterns of chordate patterning genes in a hemichordate, which suggest that the hemichordate endoderm and collar cord might be homologous to the chordate notochord and neural tube, respectively.
- Norio Miyamoto
- & Hiroshi Wada
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Interactions between Twist and other core epithelial–mesenchymal transition factors are controlled by GSK3-mediated phosphorylation
Twist is an epithelial–mesenchymal transition regulatory factor that is implicated in neural crest development and cancer. Lander and colleagues show that Twist interacts with Snail proteins to inhibit their function, and that this interaction is regulated by phosphorylation of the Twist C terminus.
- Rachel Lander
- , Talia Nasr
- & Carole LaBonne
An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm