The therapeutic benefits of biomaterials-based treatments for oral ulcer have been limited by the materials’ poor adhesion and short-time retention in oral cavity. Here, the authors report a polymer binary elastomer adhesive patch that allows water-responsive sustainable delivery of bioactive small molecules and durable adhesion to oral mucosal wounds to achieve efficient therapy of oral ulcer.
A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer