Pain management articles within Nature Communications

Featured

• Article
  28 April 2023 | Open Access

  An aptamer-based depot system for sustained release of small molecule therapeutics

  Controlled delivery of small molecule therapeutics is challenging. Here the authors report a simple and effective aptamer-based depot system where the formation of aptamer/drug complexes leads to sustained release, and using this approach demonstrate improved in vivo delivery of channel blockers.

  • Dali Wang
  • , Yang Li
  •  & Christopher B. Weldon

• Perspective
  01 March 2021 | Open Access

  Degradable polymeric vehicles for postoperative pain management

  Pain management is an extremely important topic both medically and socio-economically. Here the authors offer an overview of the use of degrading polymeric materials for delivery of pharmaceutical agents for pain management and offer a perspective of the future directions of the field.

  • Natasha C. Brigham
  • , Ru-Rong Ji
  •  & Matthew L. Becker

• Article
  16 July 2015 | Open Access

  Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

  The medial prefrontal cortex (mPFC) is implicated in pain regulation, yet the underlying mechanisms are poorly understood. Here the authors establish a critical role for mPFC in regulating pain sensation and pain-related anxiety, mediated by activation of the cyclin-dependent kinase 5 signalling pathway.

  • Guo-Qiang Wang
  • , Cheng Cen
  •  & Yun Wang