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| Open AccessAberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial diameter of the lens in subjects affected by high myopia, and find that these changes are associated with an increase in crystallin expression driven by the transcription factor MAF and TGF-β1 signaling.
- Xiangjia Zhu
- , Yu Du
- & Yi Lu
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Article
| Open AccessCCDC102B confers risk of low vision and blindness in high myopia
Myopic maculopathy is a complication of myopia that often progresses to blindness. Here, in a genome-wide association study, Hosoda et al. find that rs11873439 intronic to CCDC102B is associated with myopic maculopathy, but not with myopia, thus representing a risk factor independent of myopia.
- Yoshikatsu Hosoda
- , Munemitsu Yoshikawa
- & Kenji Yamashiro
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Article
| Open AccessMeta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.
- Qiao Fan
- , Virginie J. M. Verhoeven
- & Kari Matti Mäkelä
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Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia
Myopia is a significant and increasing public health concern. Here Miyake et al. conduct a genome-wide association study and identify WNT7Bas a susceptibility gene across different ethnic groups, suggesting a possible role in the development of myopia.
- Masahiro Miyake
- , Kenji Yamashiro
- & Nagahisa Yoshimura