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| Open AccessP2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
P2X7 receptors are purinergic receptors with pro-inflammatory functions. Here, the authors show that inhibition of leukocyte P2X7 receptors reduces dendritic spine pathology and social behavioral deficits in a mouse model of Rett syndrome.
- Juan Mauricio Garré
- , Hernandez Moura Silva
- & Guang Yang
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Article
| Open AccessPrefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior
Isolation during critical periods of development prevents development of normal social behaviours in mice, and this is thought to involve the prefrontal cortex. Here, the authors identify an activation pattern in parvalbumin-positive interneurons in the dorsal medial prefrontal cortex that when activated promotes sociability behaviours in mice.
- Lucy K. Bicks
- , Kazuhiko Yamamuro
- & Hirofumi Morishita
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Article
| Open AccessImaging brain activity during complex social behaviors in Drosophila with Flyception2
In vivo recordings of free-moving Drosophila neural activity are limited to clearly-separated flies in a stable focal plane. Here the authors improved on their Flyception imaging system to remove these constraints, and image neural activity in the male fly brain during various stages of the mating sequence.
- Dhruv Grover
- , Takeo Katsuki
- & Ralph J. Greenspan
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Article
| Open AccessInhibition within a premotor circuit controls the timing of vocal turn-taking in zebra finches
Control over when to initiate or withhold vocalizations is essential for vocal turn-taking. Here the authors investigate vocal interactions in zebra finches and show that inhibition within the premotor nucleus HVC plays an important role in the precise timing of vocal motor responses.
- Jonathan I. Benichov
- & Daniela Vallentin
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Article
| Open AccessNeural computations underlying strategic social decision-making in groups
The brain mechanisms underlying cooperation within groups, while balancing individual and collective interests, are poorly understood. Here, the authors identify the neurocomputations engaged in social dilemmas requiring strategic decisions during repeated social interactions in groups.
- Seongmin A. Park
- , Mariateresa Sestito
- & Jean-Claude Dreher
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Article
| Open AccessNeural representations of honesty predict future trust behavior
We tend to be more trusting of people who we know to be honest. Here, the authors show using fMRI that honesty-based trustworthiness is represented in the posterior cingulate cortex, dorsolateral prefrontal cortex and intraparietal sulcus, and predicts subsequent trust decisions.
- Gabriele Bellucci
- , Felix Molter
- & Soyoung Q. Park
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Article
| Open AccessEvolution of acoustic communication in blind cavefish
The fish Astyanax mexicanus has divergent cave and river-dwelling eco-morphotypes. Here, Hyacinthe et al. show that cave and river fish communicate sonically, but that the sounds produced and the responses elicited in the two morphs depend differently on the social and behavioral context.
- Carole Hyacinthe
- , Joël Attia
- & Sylvie Rétaux
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Article
| Open AccessLong-term and persistent vocal plasticity in adult bats
Bats are long-lived animals that can produce a complex vocabulary of social communication calls. Here, the authors show that even in adulthood, bats retain the ability to adaptively introduce long-term modifications to their vocalizations, showing persistent vocal plasticity.
- Daria Genzel
- , Janki Desai
- & Michael M. Yartsev
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Article
| Open AccessParadoxical impact of memory on color appearance of faces
What is the function of color vision? Here, the authors show that when retinal mechanisms of color are impaired, memory has a paradoxical impact on color appearance that is selective for faces, providing evidence that color contributes to face encoding and social communication.
- Maryam Hasantash
- , Rosa Lafer-Sousa
- & Bevil R. Conway
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Article
| Open AccessDuets recorded in the wild reveal that interindividually coordinated motor control enables cooperative behavior
Recording neural activity during coordinated behaviors in controlled environments limits opportunities for understanding natural interactions. Here, the authors record from freely moving duetting birds in their natural habitats to reveal the neural mechanisms of interindividual motor coordination.
- Susanne Hoffmann
- , Lisa Trost
- & Manfred Gahr
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Article
| Open AccessThe brain represents people as the mental states they habitually experience
Social life requires us to store information about each person’s unique disposition. Here, the authors show that the brain represents people as the sums of the mental states that those people are believed to experience.
- Mark A. Thornton
- , Miriam E. Weaverdyck
- & Diana I. Tamir
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| Open AccessPeople represent their own mental states more distinctly than those of others
The brain can represent the mental states of others, as well as those of the self. Here, the authors show that social brain manifests more distinct activity patterns when thinking about one's own states, compared to those of others, suggesting that we represent our own mind with greater granularity.
- Mark A. Thornton
- , Miriam E. Weaverdyck
- & Diana I. Tamir
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Article
| Open AccessBayesian nonparametric models characterize instantaneous strategies in a competitive dynamic game
Game theory typically models strategic human behavior using scenarios with decision constraints that poorly represent real-world social interactions. Here, the authors show it is possible to model dynamic, real-world strategic interactions using Bayesian and reinforcement learning principles.
- Kelsey R. McDonald
- , William F. Broderick
- & John M. Pearson
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Article
| Open AccessAbnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autistic-like behavioural abnormalities.
- Mohamed Edfawy
- , Joana R. Guedes
- & João Peça
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Article
| Open AccessContribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice
Recent evidence suggests that some olfactory receptor types (OR) may be indispensable to elicit certain innate odor-evoked behaviors. Here, the authors report that eliminating a single OR from the odor-activated ensemble leads to significant changes in odor perception and the evoked behavioral response.
- Nao Horio
- , Ken Murata
- & Kazushige Touhara
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Article
| Open AccessHaploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.
- Virginie Courchet
- , Amanda J. Roberts
- & Julien Courchet
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Article
| Open AccessA hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics
Although the CA2 region of the hippocampus has been implicated in social memory, its precise role has been unclear. Here, the authors show that the dorsal subregion of CA2 is required for the encoding, consolidation and recall of social memory through a circuit linking it to ventral CA1.
- Torcato Meira
- , Felix Leroy
- & Steven A. Siegelbaum
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Article
| Open AccessA scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks
An individual’s social network—their friends, family, and acquaintances—is important for their health, but existing tools for assessing social networks have limitations. Here, the authors introduce a quantitative social network assessment tool on a secure open-source web platform and show its utility in a nation-wide study.
- Amar Dhand
- , Charles C. White
- & Philip L. De Jager
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Article
| Open AccessEthanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons
Mice have been shown to display a fear response upon observing another mouse undergo fear conditioning. Here, the authors show that ethanol facilitates socially evoked fear memory recall, via pain-responsive neurons in the anterior cingulate cortex.
- Tetsuya Sakaguchi
- , Satoshi Iwasaki
- & Yuji Ikegaya
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Article
| Open AccessSleep loss causes social withdrawal and loneliness
Loneliness markedly increases mortality and morbidity, yet the factors triggering loneliness remain largely unknown. This study shows that sleep loss leads to a neurobehavioral phenotype of human social separation and loneliness, one that is transmittable to non-sleep-deprived individuals.
- Eti Ben Simon
- & Matthew P. Walker
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| Open AccessLearning auditory discriminations from observation is efficient but less robust than learning from experience
Many animals can learn, not just by direct experience, but by observing another animal performing a task. Here, the authors show in zebra finches that observer learning is efficient, but differs from direct learning in that it is less generalizable to novel stimuli.
- Gagan Narula
- , Joshua A. Herbst
- & Richard H. R. Hahnloser
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Article
| Open AccessRole of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
Individuals with autism spectrum disorder have alteration in social and novelty behaviors. Here, Bellone and colleagues show that chemogenetic inhibition of mouse dopamine neurons in the ventral tegmental area can blunt exploration towards unfamiliar conspecifics, and that these behavioral deficits are recapitulated in mice lacking neuroligin3 gene product.
- Sebastiano Bariselli
- , Hanna Hörnberg
- & Camilla Bellone
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Article
| Open AccessDevelopment of MPFC function mediates shifts in self-protective behavior provoked by social feedback
People insulate themselves against negative social feedback via self-protective behaviors. Here, the authors show that early adolescents react against immediate social feedback, but adults also consider accumulated past negative evaluations, a function mediated by the rostromedial prefrontal cortex (RMPFC).
- Leehyun Yoon
- , Leah H. Somerville
- & Hackjin Kim
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Article
| Open AccessSocial interactions impact on the dopaminergic system and drive individuality
Individual animals differ in behavioral traits, but the mechanisms underlying individuation are unclear. Here, the authors show that mice living in a ‘city’ develop individual behavior differences, associated with changes in dopamine cell firing, that can be reversed on moving them to a different social environment.
- N. Torquet
- , F. Marti
- & P. Faure
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Article
| Open AccessElucidating the genetic basis of social interaction and isolation
Little is known about the genetic determinants of social isolation and loneliness despite their well-established importance for health. Here, using multi-trait GWAS, Day et al. identify 15 genomic loci for loneliness and further show a bidirectional causal relationship between BMI and loneliness by MR.
- Felix R. Day
- , Ken K. Ong
- & John R. B. Perry
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| Open AccessReciprocity of social influence
Humans give and receive social influence—e.g. advice—in many situations, but it is not known whether social influence is a reciprocal process, like trade. Here, the authors show that people are more likely to follow a partner's advice if that partner has previously complied with their advice.
- Ali Mahmoodi
- , Bahador Bahrami
- & Carsten Mehring
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Article
| Open AccessTolerance to ambiguous uncertainty predicts prosocial behavior
Ambiguous uncertainty refers to situations where the likelihood of specific outcomes are not known. Here, the authors show that people tolerant to ambiguous uncertainty are more likely to make costly decisions to cooperate with or trust others.
- Marc-Lluís Vives
- & Oriel FeldmanHall
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Article
| Open AccessSpatial fidelity of workers predicts collective response to disturbance in a social insect
How do social insect colonies regulate tasks after the developmental stage and in response to changing environments? Here, Crall et al. use automated individual tracking to reveal that task switching after a major colony disturbance helps to maintain collective foraging performance in bumble bees.
- James D. Crall
- , Nick Gravish
- & Stacey A. Combes
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Article
| Open AccessDop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts
Migratory locusts shift between aggregating together during gregarious phases and living individually during solitary phases. Here, the authors find that the D1-like dopamine receptor regulates the olfactory attraction underlying this behavioral switch via microRNA-9a and adenylyl cyclase.
- Xiaojiao Guo
- , Zongyuan Ma
- & Le Kang
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Article
| Open AccessPredator-secreted sulfolipids induce defensive responses in C. elegans
Defensive behavioral responses can be triggered by predator-released odors. Here, the authors identified the relevant Pristionchus pacificus-released sulfolipid molecules and dissected the neural circuits underlying C. elegans response to this predator.
- Zheng Liu
- , Maro J. Kariya
- & Sreekanth H. Chalasani
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Article
| Open AccessMedial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender
The medial preoptic area (mPOA) in a mammalian brain is sexually dimorphic, and yet its exact function in mediating gender-specific behavior remains unclear. Here, Xu and colleagues show that optogenetic manipulation of the mPOA in male mice induce female-stereotyped behaviors and vice versa.
- Yi-Chao Wei
- , Shao-Ran Wang
- & Xiao-Hong Xu
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Article
| Open AccessOxytocin enhances observational fear in mice
Oxytocin modulates social behaviours in mammals. Here the authors demonstrate that observational fear, a measure of empathy-like behaviour in rodents, is modulated by oxytocin.
- Marc T. Pisansky
- , Leah R. Hanson
- & Jonathan C. Gewirtz
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Article
| Open AccessHippocampal oxytocin receptors are necessary for discrimination of social stimuli
While oxytocin is known to be critical for social recognition, the functions of oxytocin receptors (Oxtrs) in the hippocampus are not known. This study shows that Oxtrs in anterior dentate gyrus and CA2/CA3 pyramidal cells recruit population-based coding to mediate discrimination of social stimuli.
- Tara Raam
- , Kathleen M. McAvoy
- & Amar Sahay
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Article
| Open AccessMice in social conflict show rule-observance behavior enhancing long-term benefit
Resolving conflict in an orderly way is beneficial, but it is unclear whether non-human animals make and observe such rules. Here, authors show that mice spontaneously develop and observe such rules, thereby increasing their total, individual reward as well as the reward equity with other mice.
- Il-Hwan Choe
- , Junweon Byun
- & Hee-Sup Shin
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Article
| Open AccessPrior preferences beneficially influence social and non-social learning
People often assume that other people share their preferences, but how exactly this bias manifests itself in learning and decision-making is unclear. Here, authors show that a person's own preferences influence learning in both social and non-social situations, and that this bias improves performance.
- Tor Tarantola
- , Dharshan Kumaran
- & Benedetto De Martino
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| Open AccessSpecialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones
Cuticular hydrocarbons (CHC) mediate the interactions between individuals in eusocial insects, but the sensory receptors for CHCs are unclear. Here the authors show that in ants such as H. saltator, the 9-exon subfamily of odorant receptors (HsOrs) responds to CHCs, and ectopic expression of HsOrs in Drosophila neurons imparts responsiveness to CHCs.
- Gregory M. Pask
- , Jesse D. Slone
- & Anandasankar Ray
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Article
| Open AccessAutism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced learning and memory.
- Naoko Morimura
- , Hiroki Yasuda
- & Jun Aruga
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Article
| Open AccessLow-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
There is concern about potential long-term effects of antibiotics on children’s health. Here Leclercqet al. show, in mice, that low doses of penicillin during late pregnancy and early life induce lasting effects on the offspring, including alterations in gut microbiota, brain cytokine levels and behaviour.
- Sophie Leclercq
- , Firoz M. Mian
- & John Bienenstock
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Article
| Open AccessEthological principles predict the neuropeptides co-opted to influence parenting
Parental care involves shifts in numerous behaviours related to mating, feeding, aggression and social interaction. Here, the authors show that, in burying beetles, parenting is associated with increased levels of neuropeptides known to mediate these precursor behaviours, suggesting co-option of existing genetic pathways.
- Christopher B. Cunningham
- , Majors J. Badgett
- & Allen J. Moore
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Article
| Open AccessMECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.
- Keerthi Krishnan
- , Billy Y. B. Lau
- & Stephen D. Shea
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Article
| Open AccessSocial support reduces stress hormone levels in wild chimpanzees across stressful events and everyday affiliations
The stress-reducing effects of social bonds have been hypothesized to accrue either during stressful events or across daily affiliations. Here, Wittiget al. show that the presence of social partners reduces levels of stress hormones in wild chimpanzees beyond stressful contexts, supporting the latter hypothesis.
- Roman M. Wittig
- , Catherine Crockford
- & Klaus Zuberbühler
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Article
| Open AccessSocial learning strategies modify the effect of network structure on group performance
Previous studies have disagreed over whether efficient or inefficient network structures should be more effective in promoting group performance. Here, Barkoczi and Galesic demonstrate that which structure is superior depends on the social learning strategy used by individuals in the network.
- Daniel Barkoczi
- & Mirta Galesic
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Article
| Open AccessFaecal bile acids are natural ligands of the mouse accessory olfactory system
The accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of natural AOS ligands.
- Wayne I. Doyle
- , Jordan A. Dinser
- & Julian P. Meeks
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Article
| Open AccessHypothalamic CRH neurons orchestrate complex behaviours after stress
Animals exhibit a number of complex behaviours following stressful events, although the underlying circuitry is undetermined. Here, the authors use optogenetic targeting to identify a role for corticotrophin releasing hormone cells in the paraventricular nucleus in regulating such behavioural responses to acute stress.
- Tamás Füzesi
- , Nuria Daviu
- & Jaideep S. Bains
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Article
| Open AccessNeonatal face-to-face interactions promote later social behaviour in infant rhesus monkeys
Like humans, neonatal primates engage in face-to-face interactions with their mothers from an early age. Dettmer and colleagues demonstrate that in monkeys, increasing neonatal face-to-face interactions enhances social interest in infants of two and five months.
- Amanda M. Dettmer
- , Stefano S. K. Kaburu
- & Pier F. Ferrari
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Article
| Open AccessThe social contingency of momentary subjective well-being
Comparing oneself to others is inherently human but exactly how social comparison affects one's emotional state is unclear. Here the authors demonstrate that unequal social outcomes decrease happiness and these emotional impacts are proportional to individual levels of generosity.
- Robb B. Rutledge
- , Archy O. de Berker
- & Raymond J. Dolan
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Microbiota and host determinants of behavioural phenotype in maternally separated mice
There is growing evidence that the intestinal microbiota can affect host behaviour. Here, De Palma et al. show in mice that early-life stress (maternal separation) induces changes in host physiology that alter the gut microbiota, which then triggers anxiety-like and depression-like behaviour later in life.
- G. De Palma
- , P. Blennerhassett
- & P. Bercik
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Article
| Open AccessFUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization
FUS is an RNA/DNA-binding protein involved in gene expression regulation and associated with amyotrophic lateral sclerosis and frontotemporal dementia (FTLD) but the disease-causing mechanisms are unclear. Here the authors show that FUS regulates the stability of GluA1mRNA and dendritic maturation and plays a role in FTLD-associated behaviours.
- Tsuyoshi Udagawa
- , Yusuke Fujioka
- & Gen Sobue
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Fairness violations elicit greater punishment on behalf of another than for oneself
Punishment is a common response to the violation of what is perceived to be fair. Using a modified version of a well-studied ultimatum game, FeldmanHall et al.show that in fact, when presented with alternative options, people prefer not to punish unjust acts, unless the acts are directed at another person.
- Oriel FeldmanHall
- , Peter Sokol-Hessner
- & Elizabeth A. Phelps