Nuclear speckles articles within Nature Communications

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  • Article
    | Open Access

    SMNDC1 is a splicing factor that binds arginine methylation with its Tudor domain. Here, the authors study the protein’s phase-separating behavior and develop small-molecule Tudor domain inhibitors that perturb SMNDC1 function.

    • Lennart Enders
    • , Marton Siklos
    •  & Stefan Kubicek

  • Article
    | Open Access

    The cell interior is organized by diverse membrane-less condensates. Here, the authors reveal that the densities of certain condensates are surprisingly low, similar to the surrounding protoplasm and driven by cellular RNA as well as the crowded milieu.

    • Taehyun Kim
    • , Jaeyoon Yoo
    •  & Yongdae Shin

  • Article
    | Open Access

    Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.

    • Yu-Hsiu Wang
    • , Anushya Hariharan
    •  & Michael P. Sheetz

  • Article
    | Open Access

    Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.

    • Jing Ting Wong
    • , Farzanah Akhbar
    •  & Jun Wei Pek

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