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Article
| Open Access
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Matrix stiffening is a quintessential feature of aged tissues. Authors show that an aged (stiff) matrix epigenetically represses the gene encoding the longevity factor, α-Klotho, resulting in chondrocyte dysfunction, a leading cause of osteoarthritis.
- Hirotaka Iijima
- , Gabrielle Gilmer
- & Fabrisia Ambrosio
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Article
| Open Access
Regulation of bone homeostasis by MERTK and TYRO3
The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated osteolytic bone disease
- Janik Engelmann
- , Jennifer Zarrer
- & Sonja Loges
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Article
| Open Access
Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments
In this study the authors report that Caldesmon controls force-balance and architecture of stress fibers through dynamic cross-linking of actin and myosin filaments. Caldesmon depletion led to consequent problems in cell morphogenesis, motility and mechanosensing.
- Shrikant B. Kokate
- , Katarzyna Ciuba
- & Pekka Lappalainen
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Article
| Open Access
Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap.
- Jeong-Ki Kim
- , Arghavan Louhghalam
- & Dong-Hwee Kim
Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation