Thyroid hormones articles within Nature Communications

Featured

• Article
  02 May 2022 | Open Access

  Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin

  Thyroid hormones are formed within the precursor Thyroglobulin by a poorly understood process. Here Marechal et al. report a cryo-EM structure of native bovine Thyroglobulin with nascent thyroid hormone formed at a predicted hormone synthesis site.

  • Nils Marechal
  • , Banyuhay P. Serrano
  •  & Charles J. Weitz

• Article
  10 January 2022 | Open Access

  Cryo-EM structure of native human thyroglobulin

  The iodinated thyroglobulin functions as iodine storage and carrier protein and a precursor for thyroid hormone (TH) biogenesis. Here, the authors report the structure of native, fully glycosylated human thyroglobulin, revealing the location of the hTg hormonogenic and glycosylation sites.

  • Ricardo Adaixo
  • , Eva M. Steiner
  •  & Nicholas M. I. Taylor

• Article
  27 January 2017 | Open Access

  A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

  The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by enhancing fatty acid uptake of brown fat.

  • Lingling Shu
  • , Ruby L. C. Hoo
  •  & Aimin Xu

• Article
  06 March 2015 | Open Access

  Whole-genome sequence-based analysis of thyroid function

  Levels of circulating thyrotropin and free thyroxine reflect thyroid function, however, their genetic underpinnings remain poorly understood. Taylor et al. take advantage of whole-genome sequence data from cohorts within the UK10K project to identify novel variants associated with these traits.

  • Peter N. Taylor
  • , Eleonora Porcu
  •  & Pingbo Zhang

• Article | 03 June 2014

  Physiological sodium concentrations enhance the iodide affinity of the Na⁺/I⁻ symporter

  Thyroid hormone synthesis requires import of iodide ions through the Na⁺/I⁻ symporter, however its affinity for iodide is surprisingly low. Using a statistical thermodynamics approach, Nicola et al. show that sodium ion binding enhances iodide affinity, revealing a mechanism for iodide transport.

  • Juan P. Nicola
  • , Nancy Carrasco
  •  & L. Mario Amzel

• Article
  25 September 2012 | Open Access

  Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning

  Filial imprinting allows precocial birds to form social attachment to other animals or objects soon after hatching. Yamaguchi and colleagues investigate the mechanisms responsible for this, and find that thyroid hormones circulating in the plasma regulate the sensitive period during which imprinting occurs.

  • Shinji Yamaguchi
  • , Naoya Aoki
  •  & Koichi J. Homma