Tumour-suppressor proteins articles within Nature Communications

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  • Article
    | Open Access

    The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.

    • Jong Ho Park
    • , Seung Wook Yang
    •  & Chin Ha Chung

  • Article
    | Open Access

    Merlin plays a crucial role as a tumour suppressor in liver tumorigenesis. Here, the authors show that a splicing variant of Merlin that lacks exons 2,3 and 4 (Δ2–4Merlin) is highly expressed in hepatocarcinoma and promotes tumour metastasis by interfering with the binding of wild-type Merlin to ß-catenin.

    • Zai-Li Luo
    • , Shu-Qun Cheng
    •  & Zhong Li

  • Article
    | Open Access

    The formation of motile cilia is regulated by Dishevelled (DVL), a central component in WNT signalling and planar cell polarity (PCP). Here the authors identify DVL as a novel substrate of the phosphatase PTEN, coupling PTEN to cilia dynamics and PCP.

    • Iryna Shnitsar
    • , Mikhail Bashkurov
    •  & Miriam Barrios-Rodiles

  • Article
    | Open Access

    p53 can be activated by oncogenic stress to suppress tumourigenesis, but its role in radiation carcinogenesis has not been studied in p53 wild-type mice. Here, Lee et al. show that knocking down p53 during total-body irradiation not only reduces acute toxicity, but prevents the formation of radiation-induced lymphoma.

    • Chang-Lung Lee
    • , Katherine D. Castle
    •  & David G. Kirsch

  • Article |

    PTEN plays multiple roles in genome protection and tumour suppression. Here the authors show that PTEN depletion leads to impairment of replication progression, stalled fork recovery and diminished chromatin loading of Rad51, highlighting the interplay of PTEN with Rad51 in promoting stalled fork restart.

    • Jinxue He
    • , Xi Kang
    •  & Wen H. Shen

  • Article |

    Myelination of peripheral axons by Schwann cells is essential for proper transmission of nerve signals but the underlying mechanisms are not completely understood. Here the authors show that metabolic changes are required to ensure Schwann cell differentiation and proper myelination, and involve the tumour suppressor Lkb1 in regulating this process.

    • Shabnam Pooya
    • , Xiaona Liu
    •  & Biplab Dasgupta

  • Article |

    PTEN is a prominent tumour suppressor and monitoring its conformation and activity are key to developing targeted therapies. Here, the authors develop a bioluminescence resonance energy transfer biosensor for PTEN conformation and identify novel G protein-coupled receptor regulation and therapeutic activation.

    • Evelyne Lima-Fernandes
    • , Stanislas Misticone
    •  & Mark G.H. Scott

  • Article
    | Open Access

    Protein L-isoaspartyl methyltransferase (PIMT) is a carboxyl methyltransferase, but its role in regulating the tumour suppressor p53 is unclear. Here, PIMT is shown to methylate p53, obstructing the tumour suppressor function of p53 through reduced protein levels and stability.

    • Jae-Cheol Lee
    • , Sung-Ung Kang
    •  & Jeung-Whan Han

  • Article |

    PTEN is a phosphatase that regulates the phosphatidylinositol-3 kinase signalling pathway and is inactivated in many tumour types. Heet al.show that a mannosidase, α-mannosidase 2C1, can inactivate PTEN in prostate cancer cells, and that PTEN-positive human prostate tumours overexpress α-mannosidase 2C1.

    • Lizhi He
    • , Catherine Fan
    •  & Damu Tang

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