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The microbial metabolite agmatine induces polycystic ovary syndrome in mice
Agmatine produced by gut microbiota — specifically, Bacteroides vulgatus — activates the farnesoid X receptor (FXR) in intestinal epithelial L cells in a bile-acid-independent manner, which inhibits host glucagon peptide 1 (GLP-1) secretion and leads to polycystic ovary syndrome (PCOS) in mice. Supplementing mice with the GLP-1 receptor (GLP-1R) agonist liraglutide or inhibiting the production of agmatine reverses the PCOS phenotype.
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Postprandial glycaemic dips predict appetite and energy intake in healthy individuals
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Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans
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Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans