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Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.
Delay lines for quantum information are key for quantum networking and hardware efficient quantum computers. Here, the authors present a virtual delay line for microwave pulses where data is stored in the excitations of a collection of resonators, demonstrating translation and swapping of data pulses.
The authors report a zinc oxide resonant nano-accelerometer with sensitivity up to 16.818 kHz/g, which is attributed to the nano-resonators using zinc oxide nanowires and the optimized microleverages and push-pull structures.
Here, the authors develop Pangaea, an assembler that uses short-reads with long-range connectivity to create high-quality microbial genomes affordably, showing it outperforms existing methods in generating more complete genomes from both mock and real metagenomic samples.
Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.
Pathologic α-synuclein spreads from cell-to-cell through binding to the lymphocyteactivation gene 3 (Lag3). Here, the authors demonstrate that the amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 and facilitates the binding, internalization, transmission, and toxicity of pathologic α-synuclein.
There is a lack of vaccines for prevention of human respirovirus 3 (RV3) infection. Bakkers et al. report the design of a stabilized RV3 preF protein vaccine candidate that induces strong neutralizing antibodies and protective responses in small animal models.
Biaryl compounds with an axial chirality are valuable architectures but few methods have been developed for the construction of bridged biaryls, a subclass of these compounds that bear a tether to connect the two arenes and form a medium-sized ring. Here, the authors design a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization sequence of prochiral phenols for the enantioselective synthesis of biaxial bridged m-terphenyls embedded in an azocane.
The 2021 Pacific Northwest Heatwave challenged standard attribution methods. The authors use a weather model that predicted the event to quantify human impact on the heat, suggesting that such models could be used broadly to assess changing weather risk.
African swine fever virus is the sole mammalian-infecting virus encoding a type II topoisomerases (pP1192R). The authors present pP1192R structures in different states, illustrating the enzymatic mechanisms of viral type II topoisomerases.
A comprehensive understanding of the transient characteristics in solid oxide cells is crucial when integrated with intermittent renewable energy. Here, authors reveal expressions for two general characteristic times quantifying transient phenomena due to heat and mass transfer lags in SOCs.
Human HtrA2 plays an important part in the cellular protein quality control system. Here, advanced NMR spectroscopy unravels the initial activation steps of HtrA2 upon activating peptide binding and the mechanistic role of divalent cations.
The tuning properties of ventral stream neurons for object shape and category are not fully understood. Here the authors carry out multi-electrode array recordings in lateral occcipital complex and find that object properties are largely shape-based.
Frequent chromosome fusion and fission in oomycetes drive changes in chromosome number. Here, Zhang et al show that these dynamics facilitate the adaptive evolution of genes related to pathogenicity.
Replication stress induces STING-TRPV2 dissociation to promote Ca2+ release from the ER for fork protection; however, the precise mechanism remains unclear. Here, the authors identify TCAF1 as a fork protection factor that facilitates STING-TRPV2 dissociation, thereby enabling Ca2+ release.
Dbr1 exhibits debranching specificity and effect on splicing. Here the authors combine co-immunoprecipitation, RNA binding and lariat analysis and suggest a role for Dbr1 interactor AQR in intron recycling. Dbr1 depletion leads to increased dwell time of spliceosome on excised lariats.
The paralogous NLR proteins, Pit1 and Pit2, exhibit distinct functions in rice immunity, where Pit1 induces cell death on the plasma membrane and Pit2 inhibits this function by sequestering Pit1 to the cytosol.
Nanobodies are promising GPCR-targeting therapeutics. Here, the authors investigate a nanobody targeting atypical chemokine receptor 3 (ACKR3), and map trends in GPCR nanobody structure, mechanism, and selectivity.
Mosquito biting preferences and their impact on malaria transmission are not well understood. Here, the authors report findings from a longitudinal cohort study in Western Kenya which show that males aged 5-15 years tend to be bitten the most, and infectious mosquitoes appear to be more likely to bite infected individuals.
Ancestral environments can induce heritable phenotypic changes, but whether it is a common phenomenon remains unknown. This long-term experiment in Arabidopsis thaliana reveals that environment-induced heritable changes that are common, reproducible, and predictable.