Reviews & Analysis

The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency and discussing the implications of proteomics for precision medicine.

Biofortification is an effective means to reduce micronutrient malnutrition. Here, the authors review recent advances in biofortification and propose stacking multiple micronutrient traits into high-yielding varieties through the combination of conventional breeding and genetic engineering approaches.

Angiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme previously shown to mediate SARS-CoV, and now SARS-CoV-2, entry into host cells. Here the authors review existing mouse ACE2 models expressing humanized, transgenic, knockout, knockin, conditional and reporter alleles to provide a toolbox for COVID-19 research.

Tumors are more than cancer cells — the extracellular matrix is a protein structure that organizes all tissues and is altered in cancer. Here, the authors review recent progress in understanding how the cancer cells and tumor-associated stroma cells remodel the extracellular matrix to drive tumor growth and metastasis.

The social intelligence hypothesis predicts that social organisms tend to be more intelligent because within-group interactions drive cognitive evolution. Here, authors propose that conspecific outsiders can be just as important in selecting for sophisticated cognitive adaptations.

The development of high performing metal-ion batteries require guidelines to build improved electrodes and electrolytes. Here, the authors review the current state-of-the-art in the rational design of battery materials by exploiting the interplay between composition, crystal structure and electrochemical properties.

In this Perspective, the authors review the different applications for mobile phone data to support COVID-19 pandemic response, the relevance of these applications for infectious disease transmission and control, and potential sources and implications of selection bias in mobile phone data.

The strategy of modular construction makes it possible to create ordered materials with structures that are controlled at the molecular level. In this perspective article, the author shows how the approach has yielded a new generation of materials with extraordinary properties of porosity.

Structural lubricity is one of the most interesting concepts in modern tribology, which promises to achieve ultra-low friction over a wide range of length-scales. Here the authors highlight novel research lines in this area achievable by combining theoretical and experimental efforts on hard two-dimensional materials and soft colloidal and cold ion systems.

Accounting guidelines exist for carbon flows in terrestrial and coastal ecosystems, but not shelf sea sediments. In this Review, the authors explore whether effective management of carbon stocks accumulating in shelf seas could contribute to a nation’s greenhouse gas emissions reduction targets.

Photon-induced charge separation phenomena are at the heart of light-harvesting applications but challenging to be described by quantum mechanical models. Here the authors illustrate the potential of machine-learning approaches towards understanding the fundamental processes governing electronic excitations.

Despite their widespread use, many fundamental questions about the internal structure of microgels are still open. Here the authors describe several pathways toward a complete understanding of microgel colloids based on recent experimental advances in nanoscale characterization.

Adult neurogenesis is involved in several physiological and pathological processes, however standardization for the quantification of new born neurons is lacking. Here, the authors provide guidance to improve reproducibility and rigour in cell quantification.

Retinoids are involved in a wide range of cellular functions; as such, delivery systems for retinoids are of significant clinical interest. Here the authors review the advances in preclinical and clinical testing regarding retinoid formulations in the context of regenerative medicine, brain, cancer, skin and immune diseases.

Catalytic hydrogenation of amides is a pivotal chemical transformation for both research labs and chemical production in industry. Here, the authors comprehensively review this topic by including state-of-art homogeneous and heterogeneous catalysts that can hydrogenate amides and related compounds.

Why do human embryos need a yolk sac and how does it form? This Perspective by Thorsten Boroviak and Connor Ross explores the development and function of the yolk sac in primate embryogenesis.

Despite numerous advances in our understanding of subduction since the theory of plate tectonics was established, the mechanisms of subduction zone initiation remain highly controversial. Here, the authors present a transdisciplinary and expandable community database of subduction zone initiation events in the last 100 Ma, which establishes a clear direction for future research.

Scarcity of high-quality annotated data and mismatch between the development dataset and the target environment are two of the main challenges in developing predictive tools from medical imaging. In this Perspective, the authors show how causal reasoning can shed new light on these challenges.

Oceans provide important natural resources, but the management and governance of the ocean is complex and the ecosystem is suffering as a result. The authors discuss current barriers to sustainable ocean governance and suggest pathways forward.

The lack of scalable, high-quality insulators is a major problem hindering the progress on electronic devices built from 2D materials. Here, the authors review the current state-of-the-art and the future prospects of suitable insulators for 2D technologies.