Nature Methods - CURRENT ISSUE : October 2008 - Vol 5 No 10
- Monitoring protein dynamics in nanoseconds
- Classical worm genetics goes high-tech
- Multiplex human genome re-sequencing
Latest highlights
ANNOUNCEMENT
Method of the Year 2008!
Vote Now!Help us choose a Method of the Year for 2008. Vote online on methods we selected, and nominate candidate methods of your own.
ADVANCE ONLINE PUBLICATION
Positioning floppy protein domains
Article by Muschielok et al.Combining single-molecule fluorescence resonance energy transfer measurements of multiple dye pairs with probabilistic data analysis, Michaelis and colleagues monitor the position of flexible domains in macromolecular complexes. They use this method to analyze the position of RNA exiting the transcription elongation complex.
RESEARCH HIGHLIGHTS
Cell-cycle phosphoproteomics
Phosphorylation and the cell cycleFREE
Aided by recent advances in phosphopeptide enrichment methods and quantitative mass spectrometry technologies, two groups now report large-scale datasets of changes in protein phosphorylation across the cell cycle.
RESEARCH HIGHLIGHTS
Targeting local microbia
Microbes right on targetFREE
Metagenomics-based approaches for microbe discovery often involve sample collection in far-flung locations. In recent work, researchers take a look at microbes closer to home. They use a targeted approach that allows discovery of the metabolic pathways that fuel microbial growth.
RESEARCH HIGHLIGHTS
More fluorescent proteins
New twists on photoswitchable proteinsFREE
Reversibly photoswitchable fluorescent proteins are useful for a number of applications. Researchers now report new photoswitchable proteins with properties that allow multilabel imaging at a single detection wavelength and dual-color super-resolution microscopy.
Application Notes
Discover the Application Notes database, a new online resource bringing you detailed information from product suppliers about the latest reagents and instruments on the market.
Dry-state, room-temperature storage of DNA and RNA
Go to the Application Notes database
See also this month:
Application Notes from BMG Labtech, Roche, Rainin, Millipore, VisEn Medial, and Zygogen.