Constraining conformation
Peptide stapling improves stability and enhances binding. Non-symmetric stapling greatly expands the applicability of the approach, but introduces challenges of chemoselectivity and site-selectivity.
Peptide stapling improves stability and enhances binding. Non-symmetric stapling greatly expands the applicability of the approach, but introduces challenges of chemoselectivity and site-selectivity.
Structural and dynamic DNA nanosciences offer unique tools for engineering bottom–up synthetic cells. This Review provides a holistic overview for using DNA as a structural material, for designing functional entities, and for information-processing circuits for adaptive and interactive behaviour.