Vimentin tunes cell stress by assisting in both actomyosin force transmission and reinforcement of microtubule networks under compression. The competition between these two opposing effects of vimentin is regulated by the microenvironment stiffness.

This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.

Infant gray mouse lemurs performed better when they were born to mothers fed with dairy fat vs. vegetable fat in a set of tasks involving motor synchronization, sensory perception, learning and memory, suggesting an earlier psychomotor and cognitive development.

A DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A_2br-mediated adenosine signaling.

This work presents a computationally efficient approach to establish spatially fine-grained connectivity gradients, reducing computational costs while preserving informative individual features and improving brain-behavior predictions.

Time-course swRNA-seq in C. elegans reveals a three-stage process in wound repair potentially controlled by a complex gene regulatory network containing autoregulatory loops and more than 200 TFs, such as crucial factors nhr-76 and daf-16.

The study focuses on a bla_KPC-2 and bla_NDM-1 co-carrying hypertransmissible IncM1 plasmid in ST1049 CRKP strains, highlights the importance of ongoing surveillance and infection control strategies to address the challenges posed by ST1049 K. pneumoniae.

OliTag-seq, a specific and reproducible in-cellulo assay for CRISPR/Cas9 off-target analysis, can improve site cleavage efficiency and the identification of off-target sites.

This study reveals that exogenous CNP counteracts growth factor-induced pericyte alterations by preserving FoxO3 activity. Thus, impaired signaling of endogenous, paracrine-acting CNP might contribute to vascular remodeling in patients with PAH.

Apoptosis signal-regulating kinase 1 (ASK1) drives the senescence-associated secretory phenotype and contributes to immune-mediated clearance of precancerous senescent cells and age-related chronic inflammation.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.

In 2023, we conducted a virtual program to introduce early-career researchers to the fundamentals of academic journal editing. Here, we reflect on the mission of this program and its outcomes.

A comment article summarizing a range of research activities that contribute to understanding evolving Māori perspectives on Gene Editing and how they might contribute to future regulation.

Nanoparticle therapy continues to be an attractive avenue of targeted and personalised therapies. A molecular nano-conjugate developed by Zeng et al. effectively targets cancer cells and aids in their diagnosis, therapy, and also optimises innate immune responses.