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Current methods quantifying phage lytic efficacy have limits. Centroid Index quantifies efficacy via the center of area, offering more accuracy. For calculation of this index, a software called Centroid Index Calculator is presented.
Cryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.
IDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
A customized and shielded street lighting design significantly reduces the lethal attraction of flying insects in various environments. The approach harmonizes human needs with minimizing the ecological impact of artificial light at night.
A study on early life traumatic stress in mice suggest that changes in the fecal microbial community induced by early life stress can be perpetuated from exposed parent to the offspring across two generations.
Single-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
This study reports sequencing, assembly, and characterization of the genome and transcriptome of Wolfiporia cocos. In addition, Three CYP450s were identified to be involved in the biosynthesis of its active component, pachymic acid.
A metagenomic analysis of 1,142 field-collected Anopheles gambiae mosquito specimens by the Microsoft Premonition Bayesian mixture model pipeline revealed a diverse set of vertebrate hosts, as well as the presence of Plasmodium parasites and other microbes.
The bioavailability of levodopa can be enhanced with Mito-honokiol and analogs by mitigating its gut bacterial metabolism to dopamine. This finding could increase the therapeutic efficacy of levodopa in Parkinson’s disease.
Vimentin tunes cell stress by assisting in both actomyosin force transmission and reinforcement of microtubule networks under compression. The competition between these two opposing effects of vimentin is regulated by the microenvironment stiffness.
Field observations show that fish predators exhibit stronger association with warmer, still, clear waters. Here they exert heightened predation pressure on prey fish, highlighting the importance of ecological context in predator-prey dynamics.
This study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Despite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the microbiome and enhancing propionyl-CoA disposal for gluconeogenesis and fatty acid oxidation to acetyl-CoA.
A MINFLUX tracking study of a truncated kinesin-1 mutant in gently fixed primary rat hippocampal neurons revealed 8 nm substeps and a rotation of its head during the unbound state with nanometer/millisecond resolution
Structural and biochemical analysis of double-stranded RNA transporter SIDT1 reveals the conformational change associated with cholesterol binding and the causal relationship between pH, RNA binding, and ceramidase activity.
This study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
An empirical study of freshwater invertebrates is coupled with a theoretical model of metabolic ecology to show that metabolic plasticity drives species-specific differences in predator-prey interaction rates under warming.
The established HiCASE technique significantly enhances the detection of ultralow frequency mutated genes in ctDNA, promoting its application and translating basic research into clinical practice.
SMG9 deficiency in zebrafish leads to brain abnormalities, cardiac dysfunction, and premature aging due to disrupted nonsense-mediated mRNA decay and increased oxidative stress caused by elevated spermidine oxidase (Smox) levels.
An epitope binning platform based on mammalian cell surface display and DNA sequencing enables the simultaneous binning of multiple antibodies without the need for antibody production and purification.