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This article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It delves into the concept of “metacontrol”, proposing a dynamic balance of processes based on situational demands, and discusses the role of different concepts of neural dynamics in supporting adaptive behavior and understanding psychiatric disorders.
This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.
A review synthesizes interplays between photoperiodism and circadian regulation of the vegetative to reproductive transition in Arabidopsis and crops in responses to changing day lengths that ensures optimal timing for flowering and seed production.
Nucleic acids-based drugs aim to fix the genetic problem at its source and emerge as a promising new class of drugs. Recent advances in this field enabled their approval for the treatment of orphan genetic diseases for which no cure was available.
Presenting mechanisms that modulate cerebral vessel tone as interaction graphs to support research design, interpret study findings, and generate hypotheses on disease.
A review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and its functions, including the relationship between ATG7 and aging-related diseases.
A Perspective on how the tools of behavioral science and the emerging field of diverse intelligence help to understand decision-making of cellular collectives in evolutionary and biomedical contexts.
This review introduces the basic principle of fluorescence and two-photon excitation microscopy that is aimed at novice and advanced microscopists highlighting current techniques, trends, and practical guides for live imaging optimization.
The snake venom toxins responsible for tissue damage, their mechanisms of action and pathological effects are reviewed, together with the search of novel therapeutic alternatives to abrogate their effects
A theoretical framework, the Multi-Dimensional Management of Multiple Pests, is proposed to enhance the adoption of green Integrated Pest Management (IPM) tactics and encourage a more comprehensive assessment of environmental benefits.
An in-depth review compiling information about the effects of virus infections in protists and discussing how these interactions are important for cell biology, ecology and biotechnology.
This Perspective proposes that shift work adaptation occurs within-shift, over a block of shifts, or over a shift working career and offers physical activity as an accessible countermeasure to support adaptation across these timeframes.
Glymphatic and lymphatic communication contribute to the clearance of cerebrospinal fluid and the removal of macromolecules from the brain. Understanding the intricate mechanisms and the circadian influence might revolutionize treatment strategies.
In this Mini Review, the authors discuss the relationship between condensate formation, genome organization, and transcriptional activity, focusing on the experimental evidence behind the role of transcriptional condensates in gene regulation.
In this Perspective, the authors argue that it is time for biology to expand the traditional approach of observation with an engineering approach that transforms the nature of the underlying experiments to interactive context-depended design problems.
This Perspective discusses recent discoveries in DNA replication initiation, specifically focusing on minichromosome maintenance protein complexes, including details on their functioning, regulatory pathways, and implications for cancer therapies.