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TORC2 signaling, which is associated with the plasma membrane integrity, is activated by the membrane stress in S. cerevisiae. A mechanism for the negative regulation of TORC2 signaling by the cell wall integrity pathway was identified in this study.
Analysis of data from mice having spent time at the International Space Station and from a group of astronauts and a set of commercial spaceflight participants reveals alterations in genes related to insulin and estrogen signaling during spaceflight
This study highlights Bronze Age northern Eurasia as a region of interaction between various groups sharing a Siberian ancestry component and the spread of languages and cultures.
Transcriptomic profiling shows that Klotho knockout perturbs brain short non-coding RNAs, such as microRNA and tRNA fragments, in both neurons and glia, that mimics the changes associated with Alzheimer’s disease and aging in humans and murine models.
Individuals with stroke aphasia have premature brain aging in intact regions of the lesioned hemisphere. In left domain-general areas, premature brain aging significantly predicts aphasia severity, suggesting that isolate aging matters for behavior.
Mechanistic modeling of enhancer-RNA sheds light on the role of transcription factors and their interactions in the context of estrogen- induced transcriptional program in breast cancer.
The three-dimensional architecture of the host genome condenses, reorganizes, and alters its accessibility resulting in bidirectional gene expression changes in response to viral infection over time.
By contrasting brain responses to deepfake and natural speaker identities, this study reveals neural sensitivity in the reward-related nucleus accumbens when exposed to natural but not to deepfake identities.
Transcriptomics (RNA-seq) data reveal significantly increased telomeric RNA, or TERRA, in response to spaceflight and radiation exposure (compared to baseline and ground control samples).
Zhao et. al. present an immobilized antibody-based affinity grid strategy utilizing the PA tag/NZ-1 antibody system to efficiently enrich target proteins and enable streamlined on-grid purification from cell lysates for high-resolution cryo-EM.
The authors show that under the influence of metabolism, T lymphocyte activation de-condenses chromatin, disrupts the nuclear envelope, and releases DNA into the cytoplasm.
An fMRI study on anesthetized macaque monkeys examines how different depths of anesthesia uniquely affect brain networks temporal dynamics, suggesting that brain dynamics could be used as a cortical signature to gauge consciousness levels clinically.
In-insert protocol offers cost-effective, versatile, and low loss spatial quantitative proteomic analysis of FFPE tissue, identifying prolactin-induced protein as a hormonal cytoskeleton reorganization spatial biomarker in mammary tissue.
A study based on a pan-European survey of soils and riverbeds of low-anthropogenic impact suggests that environmental microbiomes with a higher degree of bacterial diversity host less diverse and lower abundances of antibiotic resistance genes.
Sirtuin’s function was studied in A. fumigatus by creating knockout strains. SirE encoding gene deletion reduces virulence, alters protein acetylation and gene expression. Sirtuin inhibitors have potential as therapy for A. fumigatus infections.
An in vitro mass cytometry study focusing on age and adjuvant-specific activation of human blood mononuclear cells reveals NK cells as the key source of TLR7/8 agonist induced innate IFNγ responses.
Based on a specificity analysis, ATRX and FANCM are discovered as substrates of NSD2. Moreover, an artificial NSD2 super-substrate is designed that is methylated very fast due to distinct hyperactive conformations of the NSD2-peptide complex.
A mathematical study of the pharmacological effects of oral chronic escitalopram in serotonin neurotransmission and how these effects are hindered by inflammatory processes.
A strategy is developed to obtain ultrahigh-affinity, single fluorescent protein-type calcium indicators (GECIs), based on the optimization of linkers in topology mutants of previously-characterized GECIs.